P269 Proposed plan for oxygen therapy as an adjuvant to antibiotics in cystic fibrosis

Although the use of modulator treatments targeting basal defect in Cystic Fibrosis transmembrane conductance regulator improves lung function and is associated with reduced burden infections, we have not seen bacterial eradication, thus antibiotic remain crucial for chronic Pseudomonas aeruginosa infection. Recent investigations shown large zones oxygen (O2) depletion infected part CF lungs due to consumption O2 by surrounding neutrophils, where aerobic respiration prevented. The restriction causes uptake antibiotics, down-regulation targets inhibited induction bactericidal amounts reactive species as P. aeruginosa. By enhancing physiology bacteria through adjuvant treatment normobaric (NBOT), can be sensitized, even clones, protected depletion, treated. We hypothesize that intermittent oxygenation (100% O2) has a beneficiary clinical impact on During first 7 out 14 days standard care treatment, one group persons (pwCF) (n = 16) will receive NBOT an oronasal mask or transparent hood 90 minutes constant flow 30 L/min [FR1] once daily. Another pwCF continue without setup. primary endpoints changes survival (CFU/mL) sputum, decreased recognized trial endpoint studies anti-infectives CF. Secondary function, production sputum neutrophils sputum. present study-plan provide proof-of-concept advantageous adults pwCF.